Melotime®

Melotime™ is a clinically validated, sustained-release melatonin ingredient designed to support the body's natural overnight melatonin profile through a convenient 1-a-Day approach. Powered by modified-release technology, Melotime™ provides a gradual release of melatonin over 7–8 hours, offering a delivery profile designed to mimic physiological nighttime melatonin secretion. Its scientific foundation includes both pharmacokinetic and clinical validation. A pharmacokinetic study demonstrated sustained release Melotime™ with a slower elimination profile than immediate-release melatonin, while a randomized, placebo-controlled clinical study showed that a 2 mg dose of Melotime™ significantly improved objective sleep parameters, including sleep efficiency, total sleep time, sleep onset latency, and nighttime awakenings, as measured by objective sleep parameters assessed using polysomnography (PSG) and subjective sleep quality assessed using the Pittsburgh Sleep Quality Index (PSQI) Designed for modern sleep formulations, Melotime™ enables brands and formulators to develop low-dose, 1-a-Day sleep solutions with sustained-release performance, formulation versatility, and consumer convenience.