Gold Buckwheat Extract

Gold Buckwheat Extract, derived from the rhizomes of Fagopyrum dibotrys (D. Don) H. Hara, is a standardized phytochemical preparation widely utilized in traditional Chinese medicine and modern nutraceutical formulations. The extract is rich in bioactive flavonoids including rutin, quercetin, and kaempferol, alongside phenolic acids such as gallic acid, chlorogenic acid, and proanthocyanidin B2, which collectively confer potent antioxidant, anti-inflammatory, and hypoglycemic properties.[^12]^ Its chemical profile is further enriched by saponins and tannins, contributing to its immunomodulatory and antimicrobial activities. Industrial extraction typically employs ethanol reflux at 60–80% concentration, followed by ultrasonic-assisted extraction to enhance yield, with final purification achieved through macroporous resin chromatography to isolate active fractions with >90% purity.[^20]^ The resulting powder form is stable, water-soluble, and suitable for encapsulation or incorporation into functional foods, dietary supplements, and topical cosmetics. Pharmacologically, the extract inhibits pro-inflammatory cytokines such as TNF-α and IL-6, suppresses NF-κB signaling, and activates the Keap1/Nrf2 pathway to upregulate endogenous antioxidant enzymes including SOD and CAT.[^19]^ In vivo and in vitro studies demonstrate its efficacy in reducing oxidative stress-induced cellular damage, particularly in hepatic and endothelial tissues, and in modulating glucose metabolism via AMPK activation.[^11]^ Clinical applications span respiratory health (e.g., adjunctive therapy for bronchitis), cardiovascular support (lipid-lowering and vasodilatory effects), and dermatological formulations for anti-aging and UV-protection.[^27]^ Marketed globally as a natural alternative to synthetic antioxidants, it is certified under HACCP, ISO9001, and FDA guidelines for use in food-grade and cosmetic products.[^25]^ Emerging research highlights its potential in functional cosmetics for inhibiti