Ligustrum Lucidum Extract

Ligustrum Lucidum Extract: A Comprehensive Overview‌ Introduction‌ Ligustrum lucidum extract, derived from the ripe fruits of Ligustrum lucidum Ait. (Oleaceae), is a traditional Chinese medicinal substance with a rich history in promoting health and longevity. Known as "Nuzhenzi" in Chinese, it has been used for centuries to tonify the liver and kidneys, enhance immunity, and address aging-related conditions. Modern research has validated its therapeutic potential, particularly in bone health, anti-inflammatory responses, and metabolic regulation. Botanical and Traditional Context‌ Ligustrum lucidum, commonly called glossy privet, is a evergreen shrub native to East Asia. Its fruits are harvested in winter, reflecting traditional practices that emphasize seasonal timing for optimal efficacy. In Chinese medicine, it is classified as a "yin-tonifying" herb, believed to nourish essential body fluids and balance internal energy. This concept aligns with its use in formulas like Erzhi Wan, where it is combined with Eclipta alba to harmonize opposing energies. Historically, it has been employed for conditions such as tinnitus, blurred vision, and premature aging, underscoring its role as a holistic remedy. Chemical Composition‌ The extract contains a diverse array of bioactive compounds, including iridoid glycosides (e.g., nuezhenide), triterpenes (e.g., oleanolic acid), flavonoids, and phenylpropanoids. These constituents contribute to its multifaceted effects: Iridoid glycosides‌: Act as functional analogs of ghrelin, modulating growth hormone pathways and potentially enhancing learning and memory. Triterpenes‌: Exhibit anti-inflammatory and antioxidant properties, with oleanolic acid improving blood fluidity and reducing platelet aggregation. Flavonoids‌: Support immune function and metabolic health, including glucose and lipid regulation.