Evodia Fructus Extract

Evodia Fructus Extract, derived from the dried nearly ripe fruits of Evodia rutaecarpa (Juss.) Benth., a plant belonging to the Rutaceae family, is a potent botanical extract with a rich history in traditional medicine. Known by various names such as Evodiae Fructus, Wu Zhu Yu in Chinese, or simply as Evodia Extract, this substance has been utilized for centuries in East Asian herbal practices for its therapeutic properties. The extract is obtained through meticulous processes that ensure the preservation of its active constituents, which include a complex array of alkaloids, volatile oils, and other bioactive compounds. The primary active components of Evodia Fructus Extract are the quinolone alkaloids, notably evodiamine and rutaecarpine. Evodiamine, with its molecular formula C19H17N3O and a molecular weight of 303.36, is a white crystalline powder that exhibits significant biological activity. It has been extensively studied for its potential in inhibiting the proliferation of cancer cells, particularly those resistant to conventional treatments. Research indicates that evodiamine can induce apoptosis and cause cell cycle arrest at the G2/M phase, showcasing its promising antitumor properties. Additionally, it has been found to be more effective than certain standard chemotherapeutic agents in specific cancer models, highlighting its potential as a novel therapeutic agent. Rutaecarpine, another key alkaloid in the extract, is known for its role in promoting blood circulation and alleviating pain. It has been used in traditional medicine to treat conditions such as headaches, abdominal pain, and menstrual discomfort. The extract also contains a variety of other compounds, including volatile oils like evodene and ocimene, which contribute to its aromatic properties and potential anti-inflammatory effects. Furthermore, it includes limonoids, flavonoids, and other secondary metabolites that enhance its therapeutic profile.