Achyranthes Bidentata Extract

Achyranthes bidentata extract is a standardized phytochemical preparation derived from the dried roots of Achyranthes bidentata Blume, a perennial herb native to East Asia and traditionally cultivated in Henan, Shanxi, and Shandong provinces of China, where it is known as “Huai Niu Xi” or “Huai Achyranthes.” This extract is primarily composed of triterpenoid saponins including achyranthosides, ecdysterone (a potent phytoecdysteroid), polysaccharides, and steroidal compounds, which collectively confer its broad pharmacological profile. Modern research confirms its anti-inflammatory, antioxidant, immunomodulatory, and osteoprotective activities, with particular efficacy in mitigating osteoporosis by stimulating osteoblast differentiation and suppressing osteoclastogenesis via the MAPK/AKT signaling pathway. It also demonstrates neuroprotective effects through inhibition of neuronal apoptosis and reduction of microvascular thrombosis in ischemic stroke models, as well as vasodilatory and antihypertensive actions beneficial in cardiovascular and cerebrovascular disorders such as coronary heart disease and cerebral arteriosclerosis. In traditional Chinese medicine, it is prescribed to tonify the liver and kidneys, strengthen sinews and bones, promote blood circulation, and unblock collaterals, making it a cornerstone remedy for lower back and knee pain, rheumatic arthralgia, and gynecological conditions including amenorrhea and dysmenorrhea. Commercially, the extract is produced as a brown to pale yellow fine powder with typical ratios of 5:1, 10:1, or 20:1, standardized by HPLC for active marker compounds, and packaged in aluminum foil bags or paper drums for use in dietary supplements, functional foods, cosmetics, and veterinary formulations. It is widely exported under the English name Achyranthes bidentata extract, with major producers based in Shaanxi and Henan, adhering to ISO9001, HACCP, and KOSHER certifications.